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<\/figure><\/div>\n<\/div>\n\n\n\nNicole Brown<\/strong> serves as Chief Innovation Officer for Open Book Extracts (OBX), an ingredient manufacturer and product development house focused on cannabinoid-enabled health and wellness, located in North Carolina. As Chief Innovation Officer, Nicole channels data-driven consumer insights into a long-term course of action, delivering immediately usable innovation, and drives awareness and thought leadership by overseeing strategic marketing efforts, including PR, event marketing, advertising, and partnerships.<\/p>\n<\/div>\n<\/div>\n\n\n\n Exclusive interview with The 420 Area Code<\/em><\/p>\n\n\n\n 420AC: How does CBD work in the body?<\/strong><\/p>\n\n\n\n Ms. Brown:<\/strong> The human body is a complex machine, and the way it interacts with any compound, including Cannabidiol (CBD) can be even more so. CBD (Cannabidiol) is one of over 100 compounds found in hemp and marijuana. It\u2019s the second most prevalent compound (second only to THC) in cannabis. CBD belongs to a class of molecules called phyto-cannabinoids and is non-psychoactive.<\/p>\n\n\n\n All cannabinoids, including CBD, produce effects in the body by attaching to certain receptors belonging to the endocannabinoid system. The Endocannabinoid System (ECS), named after the plant that led to its discovery, is perhaps the most important physiological system involved in establishing and maintaining human health. Endocannabinoids are some of the most versatile and widespread molecules. The system plays a major role in balancing many important functions. The endocannabinoid system also isn\u2019t unique to humans. Scientists have found that the ECS exists in any animal with a vertebra, including fish, reptiles, birds, and mammals.<\/p>\n\n\n\n The endocannabinoid system (ECS) plays a very interesting and varied role within the body. At its most basic, the endocannabinoid system is a huge network of cannabinoid receptors which are spread through the body. The human endocannabinoid system releases cannabinoids that interact with receptors found in virtually all of the tissues in our bodies. You can also take in phyto-cannabinoids (CBD) in addition to those compounds that your body produces to help boost this system. The role of the endocannabinoid system is to bring balance to our tissues, including the heart, digestive, endocrine, immune, nervous, and reproductive systems. In short, it\u2019s working to keep you in neutral. Neutral means different things in different areas of your body, which is possibly one of the very best things about the compound \u2013 it can have a different impact on different receptors in your body.<\/p>\n\n\n\n Cannabinoid receptors are found throughout the human body embedded in the cell membranes that are responsible for regulating multiple processes that we experience daily including mood, appetite, memory, and pain sensation. When they\u2019re activated, it can be by naturally occurring endocannabinoids, as well as by the phyto-cannabinoids found in hemp and cannabis.<\/p>\n\n\n\n There are two major cannabinoid receptors \u2013 CB1 and CB2 (Researchers speculate there may be a third cannabinoid receptor waiting to be discovered.)<\/p>\n\n\n\n Scientists once believed that CBD attached to the CB2 receptors, but new studies have indicated that CBD does not attach directly to either receptor. Instead, it\u2019s believed that CBD influences the endocannabinoid system indirectly.<\/p>\n\n\n\n When someone takes CBD, the compound goes into your system and to the endocannabinoid system (ECS). Since cannabidiol has been found to have no particular binding affinity, scientists believe CBD\u2019s therapeutic benefits created via indirect action.<\/p>\n\n\n\n CBD inhibits fatty acid amide hydrolase (FAAH), which breaks down anandamide and weakens it. CBD weakens FAAH, which leads to an increased concentration of anandamide. Anandamide is considered the \u201cbliss molecule\u201d and plays an important role in the generation of pleasure and motivation. The increased concentration of anandamide can have a positive effect on the endocannabinoid system.<\/p>\n\n\n\n CBD also affects the fatty acid binding protein (FABP). FABP proteins bind to anandamide and transport the enzyme outside the synapse to broken down and metabolized by the FAAH. CBD affects the transportation process of FABP so that less anandamide is metabolized, again resulting in a higher concentration of anandamide.<\/p>\n\n\n\n Finally, CBD binds itself to the G-protein receptors known as TRPV-1. TRVP-1 receptors are involved in regulating pain, body temperature, and inflammation. It is through this bind that scientists believe CBD helps with inflammation and pain relief.<\/p>\n\n\n\n 420AC: What health benefits does CBD really provide?<\/strong><\/p>\n\n\n\n Ms. Brown:<\/strong> Cannabidiol (CBD) is a popular natural remedy used for many common ailments — it is one of over 100 chemical compounds known as cannabinoids found in the cannabis or marijuana plant, Cannabis sativa (1<\/u><\/a>).<\/p>\n\n\n\n Tetrahydrocannabinol (THC) is the main psychoactive cannabinoid found in cannabis and causes the sensation of getting \u201chigh\u201d that\u2019s often associated with marijuana. However, unlike THC, CBD is not psychoactive.<\/p>\n\n\n\n This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of marijuana or certain pharmaceutical drugs. It\u2019s gaining momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain and anxiety.<\/p>\n\n\n\n Here are seven health benefits of CBD oil that are backed by scientific evidence.<\/p>\n\n\n\n 1. Can Relieve Pain<\/strong><\/p>\n\n\n\n More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects. The human body contains a specialized system called the endocannabinoid system (ECS)<\/u><\/a>, which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response (3<\/u><\/a>). The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system.<\/p>\n\n\n\n 2. Could Reduce Anxiety and Depression<\/strong><\/p>\n\n\n\n Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being. According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth (9<\/u><\/a>). Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction, and headache (10)<\/u><\/a>. What\u2019s more, medications like benzodiazepines can be addictive and may lead to substance abuse (11<\/u><\/a>)<\/p>\n\n\n\n CBD has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach.<\/p>\n\n\n\n 3. Can Alleviate Cancer-Related Symptoms<\/strong><\/p>\n\n\n\n CBD may help reduce symptoms related to cancer and side effects related to cancer<\/u><\/a> treatment, like nausea, vomiting and pain.<\/p>\n\n\n\n 4. May Reduce Acne<\/strong><\/p>\n\n\n\n Acne is a common skin condition that affects more than 9% of the population (21<\/u><\/a>). It is thought to be caused by a number of factors, including genetics, bacteria, underlying inflammation and the overproduction of sebum, an oily secretion made by sebaceous glands in the skin (22,<\/u><\/a> 23<\/u><\/a>). Based on recent scientific studies, CBD oil may help treat acne due to its anti-inflammatory properties and ability to reduce sebum production.<\/p>\n\n\n\n 5. Might Have Neuroprotective Properties<\/strong><\/p>\n\n\n\n Researchers believe that CBD\u2019s ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders. In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis. Though research in this area is still relatively new, several studies have shown promising results. Sativex, an oral spray consisting of CBD and THC, has been proven to be a safe and effective way to reduce muscle spasticity in people with multiple sclerosis.<\/p>\n\n\n\n 6. Could Benefit Heart Health<\/strong><\/p>\n\n\n\n Recent research has linked CBD with several benefits for the heart and circulatory system, including the ability to lower high blood pressure.<\/p>\n\n\n\n 7. Several Other Potential Benefits<\/strong><\/p>\n\n\n\n CBD has been studied for its role in treating a number of health issues other than those outlined above.<\/p>\n\n\n\n Though more studies are needed, CBD is thought to provide the following health benefits:<\/p>\n\n\n\n 420AC: What are the most notable CBD flower effects?<\/strong><\/p>\n\n\n\n Ms. Brown:<\/strong> CBD flower is the bud of the hemp plant. Hemp is cannabis with less than 0.3% THC, the part of the marijuana plant that gets you high. While THC can drastically alter your mood and perception, the cannabinoid CBD may treat a variety of aches, pains, and other conditions. For this reason, hemp-based CBD has become a sought-after foundation for therapeutic oils. CBD compounds mixed with essential oils are frequently used as creams, tinctures, and blends for massage therapy and other uses.<\/p>\n\n\n\n Any health advantages that CBD offers may also be present in CBD hemp flower. In addition, because hemp flower contains negligible THC, it is not addictive. While hemp products may not produce the euphoria that many cannabis users seek, they also do not lead to unwanted side effects like brain fog and memory issues.<\/p>\n\n\n\n Consumption method also influences how beneficial flower can be for you. If you have a respiratory condition, such as asthma, smoking or vaping flower would not be the best choice<\/p>\n\n\n\n 420AC: What is the difference between broad-spectrum CBD, full-spectrum CBD, and CBD Isolate?<\/strong><\/p>\n\n\n\n Ms. Brown:<\/strong> The difference between broad spectrum, full spectrum and CBD isolate is simply the chemical compound content found in each of the products.<\/p>\n\n\n\n 420AC: The Entourage Effect is often talked about. What is it?<\/strong><\/p>\n\n\n\n Ms. Brown:<\/strong> A growing number of researchers believe CBD can produce superior results when administered in a more natural form, either together or in combination with other chemical compounds found in cannabis plants like the minor cannabinoids, terpenes, and flavonoids. Such compounds are often referred to as whole-plant or full-spectrum products.<\/p>\n\n\n\n They claim this is the result of a theoretical principle known as the entourage effect. While some still have doubts, experimental and anecdotal evidence has convinced many cannabis consumers and industry professionals that the entourage effect is real.<\/p>\n\n\n\n The entourage effect is believed to emerge from the interactions between cannabinoids and between terpenes and cannabinoids. Terpenes are essential oils with distinctive aromas and flavors, and the characteristics of individual cannabis products are often determined by their relative concentrations of specific terpenes. Currently, most of the research into the entourage effect has focused on the interactions between THC and CBD, and more specifically, on how the latter might affect the former.<\/p>\n\n\n\n \u201cThe biggest influence [on THC] is CBD,\u201d states Ethan Russo, a neurologist who serves as Director of Research and Development at the International Cannabis and Cannabinoids Institute in Prague. Perhaps no one in the industry has gone to greater lengths to prove the existence of the entourage effect than Russo, who has been scouring the scientific literature in search of its footprints<\/u><\/a> for decades.<\/p>\n","protected":false},"excerpt":{"rendered":" Nicole Brown serves as Chief Innovation Officer for Open Book Extracts (OBX), an ingredient manufacturer and product development house focused on cannabinoid-enabled health and wellness, located in North Carolina.<\/p>\n","protected":false},"author":5,"featured_media":406,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/posts\/188"}],"collection":[{"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/comments?post=188"}],"version-history":[{"count":0,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/posts\/188\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/media\/406"}],"wp:attachment":[{"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/media?parent=188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/categories?post=188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/the420areacode.com\/wp-json\/wp\/v2\/tags?post=188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
addiction. In rats, CBD has been shown to reduce morphine dependence and
heroin-seeking behavior (37)<\/u><\/a><\/li>![\"\"](\"https:\/\/the420areacode.com\/wp-content\/uploads\/2021\/09\/isolate-full-broad-spectrum-cbd.png\")
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